Pavin Smith clubbed a pinch-hit, walk-off two-run homer with one out in the bottom of the ninth inning to give the Arizona Diamondbacks a 4-2 victory over the San Francisco Giants on Monday night at Phoenix in the opener of a three-game series.

Jake McCarthy doubled to left field off Randy Rodriguez (1-1) and Smith followed by drilling a fastball that barely cleared the wall in center. The 424-foot blast gave Arizona its third straight victory. Lourdes Gurriel Jr. hit his 100th career homer and Blaze Alexander had two hits and one RBI for the Diamondbacks.

Heliot Ramos homered for the Giants, who lost their fifth straight game -- but briefly believed they had taken the lead in the ninth inning.

With runners on the corners, Jorge Soler hit a bouncer to third. The throw by Eugenio Suarez was high and Soler was ruled to have touched the base before he was tagged by Arizona's Christian Walker. But a review showed that Walker made the tag before Soler's foot came down on the bag, erasing the would-be go-ahead run and keeping the game tied entering the bottom of the ninth.

Phillies 3, Brewers 1

David Dahl hit a solo home run and a single, Zack Wheeler tossed seven strong innings and host Philadelphia defeated Milwaukee.

Johan Rojas added two singles and an RBI for the Phillies, and Edmundo Sosa had an RBI single. Wheeler (7-3) allowed five hits and one run to go along with six strikeouts and three walks. Jeff Hoffman pitched a scoreless eighth, and Jose Alvarado logged a 1-2-3 ninth for his 10th save of the season.

Facing his former team, Rhys Hoskins hit a solo home run for the Brewers. Blake Perkins had two hits. Milwaukee had its five-game winning streak snapped.

Tigers 2, Rangers 1

Jake Rogers hit a pair of solo homers as Detroit opened a three-game series with a victory in Arlington, Texas. Rogers broke a 1-1 tie with a two-out homer in the eighth inning against Jose Leclerc (3-4).

Beau Brieske (1-0) pitched three scoreless innings of relief for Detroit, which won its second straight game despite being held to four hits.

Marcus Semien homered and Wyatt Langford tripled and singled for the Rangers, who went 0-for-7 with runners in scoring position. Nathan Eovaldi gave up one run in 5 2/3 innings.

Orioles 7, Blue Jays 2

Austin Hays had two home runs and three RBIs, Anthony Santander hit a two-run homer and visiting Baltimore defeated Toronto.

Ramon Urias added a solo shot for the Orioles, who have won nine of their past 11 games. Second baseman Connor Norby made his major league debut and went 0-for-3 with two strikeouts. He is the No. 6 prospect in Baltimore's organization, according to MLB Pipeline. Baltimore starter Grayson Rodriguez (6-2) held Toronto to two runs (one earned) and seven hits in 6 2/3 innings. Rodriguez didn't issue a walk and struck out four.

Vladimir Guerrero Jr. hit a solo home run for the Blue Jays, who are 2-2 on their seven-game homestand. Monday marked the opener of a four-game series. Toronto starter Kevin Gausman (4-4) allowed six runs, six hits and one walk in 6 1/3 innings. He fanned three.

Astros 7, Cardinals 4

Yainer Diaz socked a tiebreaking, two-run home run with two outs in the eighth inning to help Houston complete a comeback victory over visiting St. Louis.

The Astros pulled even at 4-4 earlier in the eighth when Alex Bregman rallied from an 0-2 hole to drill his ninth home run, a leadoff shot against JoJo Romero (2-1). It was the 174th career homer for Bregman, who tied George Springer for sixth place in club history. Four Astros relievers combined to toss four shutout innings. Closer Josh Hader notched his ninth save with a perfect ninth. Rafael Montero (1-1) earned the victory in relief.

Cardinals second baseman Nolan Gorman clubbed a pair of homers off Astros right-hander Justin Verlander, who surrendered four runs on seven hits and two walks with four strikeouts over five innings. The Cardinals tagged Verlander for two solo homers in the top of the first, with Alec Burleson spotting St. Louis a 1-0 lead with his seventh home run two batters before Gorman socked his 12th homer 407 feet to right-center.

Mets 8, Nationals 7

Starling Marte and Jose Iglesias each had three hits as visiting New York held off Washington.

Mark Vientos homered, singled and walked twice for New York. Starter Tylor Megill (1-2) struggled but completed five innings while giving up five runs -- four earned -- on seven hits. He walked three and struck out four. Adrian Houser pitched 2 1/3 scoreless innings of relief to help the Mets end a two-game skid.

The Nationals rallied for two runs in the bottom of the ninth before Jake Diekman struck out Drew Millas with runners at first and third for his second save. Joey Gallo homered while Jesse Winker logged three hits and three RBIs for the Nationals, who have lost three of their past four games. Washington starter MacKenzie Gore (4-5) allowed six runs on seven hits in 4 1/3 innings.

Angels 2, Padres 1

Luis Guillorme's pinch-hit sacrifice fly in the eighth inning snapped a tie and lifted Los Angeles to a victory over San Diego in Anaheim, Calif.

Jo Adell began the winning rally with a double to right field off Adrian Morejon (1-1), then tagged and went to third on Zach Neto's flyout to right-center. Padres manager Mike Shildt brought in reliever Jeremiah Estrada to pitch to Kyren Paris, but Angels manager Ron Washington countered and sent Guillorme up to pinch-hit.

Manny Machado hit a solo shot for the Padres. Los Angeles reliever Hunter Strickland (2-1) threw 1 1/3 scoreless innings to earn the win.

Reds 13, Rockies 3

Jeimer Candelario homered and doubled, Tyler Stephenson also went deep as part of a 2-for-5 night and Cincinnati hammered Colorado in Denver.

Jonathan India and Spencer Steer had three hits apiece and TJ Friedl and Will Benson each had two for Cincinnati, which finished with a season-high 18. The 13 runs were also a season high. Reds starter Andrew Abbott (4-5) allowed three runs on seven hits in six innings. He walked one and struck out six.

Brendan Rodgers homered and finished with two hits while Brenton Doyle contributed three hits for Colorado, which has dropped three in a row. In 4 1/3 innings, Rockies starter Ryan Feltner (1-5) allowed eight runs on 10 hits. He didn't walk anyone and fanned three.