Cedric Mullins hit an RBI single with one out in the 10th inning off Clay Holmes as the Baltimore Orioles blew a four-run lead before holding on for a 7-6 victory over the host New York Yankees on Wednesday night, spoiling the season debut of right-hander Gerrit Cole.

Mullins snapped the tie by hitting a bloop single to center field on a 1-1 pitch by Holmes (1-3) that scored automatic runner Anthony Santander ahead of the throw to the plate. Mullins stole third and gave the Orioles a 7-5 lead when catcher Jose Trevino's throw sailed into left field.

Cole allowed two runs on three hits in four-plus innings in his first start since a right elbow injury. He struck out five and walked one during his 62-pitch outing.

The Yankees lost for the fourth time in six games and played without Aaron Judge. Judge was held out as a precaution after getting hit in the left hand in the third inning on Tuesday.

Cubs 6, Giants 5

Kyle Hendricks struck out a season-high eight batters in his first start in over a month as Chicago held on to beat visiting San Francisco in the rubber match of a three-game series.

Hendricks (1-4) limited the Giants to one run on two hits and a walk over 5 2/3 innings in his first start since May 17. Ian Happ and Dansby Swanson each had two hits for the Cubs, and they hit back-to-back solo home runs in the fourth inning.

Jorge Soler hit a grand slam in the eighth inning for San Francisco to make it a one-run game. Right-hander Spencer Bivens (1-1) took the loss.

Pirates 1, Reds 0

Bryan Reynolds extended his hitting streak to 17 games, the longest in the majors this season, with a two-out homer in the eighth inning, and Pittsburgh edged visiting Cincinnati in the rubber match of a three-game series.

Reynolds deposited a 1-0 changeup from Nick Martinez (2-5) over the center field wall for his 10th homer this season. Reynolds' 17-game hitting streak matches his career high.

Colin Holderman (3-0) pitched a scoreless eighth inning for the win after Mitch Keller went seven innings, allowing two hits. David Bednar retired the Reds in order in the ninth for his 16th save. Hunter Green went 6 1/3 innings for the Reds, allowing only two hits.

Braves 7, Tigers 0

Sean Murphy hit two home runs and Reynaldo Lopez (5-2) pitched five scoreless innings to spark host Atlanta to a shutout of Detroit and a sweep of their three-game series.

The Braves have won three straight and six of their past seven. The Tigers have lost four in a row.

Murphy went 4-for-4 with four RBI, three runs scored and produced the fourth multi-homer game of his career. He hit a two-run homer over the brick wall in right field in the third inning, his first career hit against Tigers starter Tarik Skubal (8-3). His other homer was a two-run shot in the fifth.

Marlins 4, Cardinals 3

Otto Lopez laced an opposite field walk-off single over reliever Ryan Fernandez (0-2) to score Tim Anderson and deliver host Miami to a win over St. Louis, the second in the three-game series.

With two outs in the ninth, Lopez lined a 2-0 pitch to right field between first and second base and Cardinals right fielder Alec Burleson lost the handle on the ball attempting to make a throw to the plate as Anderson came around from second base.

Yonny Chirinos made his Marlins debut and went five innings, allowing eight hits and two runs in a no-decision. Tanner Scott (6-5) earned the win with a ninth inning of relief.

Padres 5, Phillies 2

Kyle Higashioka had a three-run triple as visiting San Diego defeated Philadelphia to take the series finale.

The Padres broke a five-game losing streak and avoided being swept in six games this season by Philadelphia. They also denied the Phillies, who lost for the fifth time in eight games, their National League-best 50th win.

Phillies left-hander Ranger Suarez and San Diego right-hander Matt Waldron started off by allowing only a solo homer each for six innings: by rookie Jackson Merrill for the Padres and Bryce Harper for the Phillies. Waldron (5-6) got the win and Robert Suarez earned his 18th save. Orion Kerkering (2-1) took the loss.

Nationals 3, Diamondbacks 1

Jesse Winker hit a two-run home run in the sixth inning and Washington rallied for a win against visiting Arizona.

With Washington trailing 1-0, Lane Thomas drew a two-out walk against Arizona starter Brandon Pfaadt, and Winker homered to center on an 0-1 fastball to give Washington the lead.

Derek Law (4-2) pitched two perfect innings of relief for the win, and Kyle Finnegan worked the ninth for his 21st save of the year. Brandon Pfaadt (3-6) worked 6 1/3 innings and was charged with three runs on five hits and four walks.

Guardians 8, Mariners 0

Tanner Bibee pitched six scoreless innings and struck out a career-high 12 batters as Cleveland defeated visiting Seattle.

Josh Naylor hit two home runs to surpass Jose Ramirez for the team lead and Steven Kwan also went deep for the Guardians, who snapped a three-game skid.

The Mariners had a four-game winning streak come to an end and suffered just their second loss in the past 10 games.

Red Sox 7, Blue Jays 3

Enmanuel Valdez and Jarren Duran hit solo home runs and visiting Boston defeated Toronto.

Duran also had an RBI single to help the Red Sox sweep the three-game series and extend their winning streak to five games.

Blue Jays right-hander Kevin Gausman (5-6) allowed five runs (four earned) on six hits and three walks while striking out four in 5 2/3 innings.

Astros 4, White Sox 1

Hunter Brown threw six quality innings and Cesar Salazar drove in a pair of runs on two hits, helping Houston defeat host Chicago.

Brown (4-5) allowed just one run on seven hits and struck out six in picking up his third consecutive win. Jose Altuve and Jake Meyers also had two hits each for the Astros, who have won two of their last three games.

Andrew Benintendi rapped a solo homer and Korey Lee and Luis Robert each had two hits for Chicago, which has lost seven of 10.

Rangers 5, Mets 3

Slumping Leody Taveras hit a tiebreaking two-run homer in the seventh inning to help struggling Texas defeat streaking New York in Arlington, Texas. Wyatt Langford had two hits and two RBIs for the Rangers, who snapped a five-game skid while halting New York's season-best seven-game winning streak.

Taveras was just 3-for-49 this month when he came up against Drew Smith (1-1) with two outs in the seventh and Corey Seager on first. On the seventh pitch of the at-bat, Taveras smacked the decisive homer to right-center, his fifth blast of the season.

Pete Alonso slugged a two-run homer for the Mets and has 10 RBIs over the past four games. But New York had just five hits two nights after racking up a season-best 22.

Rays 3, Twins 2 (10 innings)

Randy Arozarena scored on a throwing error with two outs in the top of the 10th inning as visiting Tampa Bay rallied for a win over Minnesota.

Jonny DeLuca hit a grounder to third baseman Royce Lewis, who hit a solo homer earlier but pulled a throw wide of first base. Carlos Santana's futile dive couldn't keep the ball from bouncing into foul ground as Arozarena made it home from second.

Jason Adam (4-1) worked a 1-2-3 ninth and Phil Maton did the same in the 10th to earn his second save. Tampa Bay's Taj Bradley scattered seven hits and allowed two runs in six innings, while Minnesota's Joe Ryan permitted six hits and a run in six innings.

Brewers 2, Angels 0

Freddy Peralta threw six scoreless innings and got just enough support from his offense as Milwaukee beat Los Angeles in Anaheim, Calif.

Peralta (5-4) outpitched counterpart Tyler Anderson (6-7), who gave up just one run in seven innings but took the loss. Peralta gave up three hits -- all singles --while striking out eight and walking two in 101 pitches.

The Angels had opportunities against Peralta, but the right-hander kept Los Angeles hitless (0 for 7) with runners in scoring position.

Rockies 7, Dodgers 6

Brenton Doyle hit a sacrifice fly in the bottom of the ninth inning as Colorado rallied to beat Los Angeles in Denver. It was redemption for Colorado, which blew a five-run, ninth-inning lead Tuesday night in an 11-9 loss.

Michael Toglia homered and tripled, Ryan McMahon and Adael Amador each had two hits and Jalen Beeks (3-3) got the win with a scoreless inning of relief for the Rockies.

Shohei Ohtani had two hits and drove in three runs and Freddie Freeman and Andy Pages had two hits each for Los Angeles.

Athletics 5, Royals 1

Luis Medina snapped a personal 11-month losing streak, Brent Rooker drove in a pair of runs and Oakland made it two straight over visiting Kansas City.

Zack Gelof homered and Miguel Andujar collected three hits, scored a run and drove in another for the A's, who won back-to-back games for the first time since their six-game winning streak that began in late April.

Bobby Witt Jr. had a double and a single for the Royals, who dropped their third straight. Kyle Isbel also had two of Kansas City's eight hits.