Tampa Bay Buccaneers wide receiver Sterling Shepard will move into the No. 2 role ahead of Sunday's matchup against the San Francisco 49ers. The Bucs will be without Mike Evans (hamstring) and Chris Godwin (leg) for Sunday's game. That means, Shepard will move up the depth chart this weekend. The 32-year-old has hauled in four receptions in three of the first five games. The problem has been the yardage as Shepard has 39 receiving yards or less in every game but one. There should be a handful of targets coming Shepard's way, but it's unclear what damage he'll do on the field. In most formats, Shepard should be viewed as a flex option for Week 6.

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Miami Dolphins quarterback Tua Tagovailoa will face the Chargers in a tough test at home during Week 6. Last week, Tua had one of his best games of the year, even though he was playing his first game without top receiver Tyreek Hill (knee). He completed 27-of-36 pass attempts for 256 passing yards and three touchdowns. He has thrown multiple touchdowns in four straight weeks and is up to 10 touchdowns on the year with just four interceptions. He's averaging just over 200 passing yards per game, while adding almost no rushing production. His recent success has been in favorable matchups, but this week, he'll face the Chargers, who have allowed the seventh-fewest fantasy points to the position. They have allowed just four passing scores all year and an average of only 188.2 passing yards per game. In the tough matchup, Tua is the No. 23 QB in RotoBaller's rankings, making him a borderline second QB but not a starter in most standard leagues.

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Tampa Bay Buccaneers running back Sean Tucker moved into the No. 2 role in the backfield during last week's game against the Seattle Seahawks. The assumption was that Tucker would see a handful of carries with Bucky Irving (foot) sidelined. Tucker didn't see much of the field as Rachaad White did most of the work on offense. Tucker rushed the ball three times for three yards while hauling in three passes for -4 yards in the win. The expectation is that Tucker will see a handful of touches this weekend, but isn't a trustworthy starter. Fantasy managers should keep Tucker on the bench for the Week 6 matchup against the San Francisco 49ers.

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Cincinnati Bengals star wide receiver Ja'Marr Chase (illness), who was listed as questionable for Week 6 on Sunday after missing Friday's practice due to an illness, is expected to play against the Green Bay Packers at Lambeau Field, sources told Matt Zenitz of CBS Sports. Chase was feeling a little under the weather on Friday, but he should be fine to play in a couple of days in what will be new quarterback Joe Flacco's starting debut in Cincinnati. The 25-year-old Chase has had three quiet games and two 100-yard games so far in 2025. A 6-110-2 line in last week's loss to the Detroit Lions proves why Chase is still a must-start in fantasy despite quarterback Joe Burrow (toe) potentially being out for the rest of the year. It remains to be seen what kind of chemistry Chase will have with Flacco, but the veteran signal-caller figures to target him heavily.

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Tampa Bay Buccaneers wide receiver Emeka Egbuka was unstoppable during last week's game against the Seattle Seahawks. Egbuka hauled in all seven of his targets for 163 yards and a touchdown in the win. The rookie wideout has now posted back-to-back games with at least 100 receiving yards. The Bucs are going to be without Mike Evans (hamstring) and Chris Godwin (leg) for Sunday's game against the San Francisco 49ers. That being said, Egbuka is expected to serve as the focal point in the receiving game. The 22-year-old has shown no signs of slowing down so he belongs as a strong WR1 for Week 6.

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Tampa Bay Buccaneers running back Rachaad White is set to make another start this Sunday versus the San Francisco 49ers. White made his first start of the season during last week's win over the Seattle Seahawks. The 26-year-old rushed 14 times for 41 yards with two touchdowns. He also hauled in four receptions for an additional 30 yards through the air. White figures to remain a focal point on offense with Bucky Irving (foot), Mike Evans (hamstring), and Chris Godwin (leg) all expected to miss Week 6. The Bucs really have no choice but to get White involved. He's a capable option in both the running and receiving game, which gives him borderline RB1 value for this weekend.

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Washington Commanders running back Jeremy McNichols worked mostly behind rookie Jacory Croskey-Merritt in Week 5, rushing just once for six yards and catching one of two targets for 12 yards. McNichols matched third-year running back Chris Rodriguez Jr. in snaps, each playing 13 snaps, while Croskey-Merritt led the way with 28. McNichols' role in pass protection is highly valued by the Washington coaching staff and will keep him involved in Washington's backfield committee. But his floor for touches is low, which limits his appeal in fantasy.

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Washington Commanders running back Jacory Croskey-Merritt broke out with his best game of the season in Week 5 against the Chargers, totaling 150 yards and two touchdowns on 16 touches. The Croskey-Merritt takeover finally happened in Week 5, posting a season-high 50.9% snap share, handling 50% of the team's rush attempts, and running 31.3% of the team's routes. All marks were the highest of any Washington back in Week 5, and he delivered with a remarkable performance. For the season, he's rushed 283 yards and four touchdowns on 43 carries, averaging a league-best 6.6 yards per carry. Offensive coordinator Kliff Kingsbury provided some reason to keep the optimism in check, saying that the rookie still has "ways to go" in terms of playing without the ball in his hands. His work in pass protection has improved, but that is still an area where veteran Jeremy McNichols is most trusted. Third-year back Chris Rodriguez Jr. saw his lowest snap count and fewest carries in a game since becoming active in Week 5, suggesting he may be slipping back into a depth role. Croskey-Merritt should be expected to handle the bulk of the touches again in Week 6 against a Bears defense that is allowing an absurd 6.1 yards per carry and the fourth-most PPR points per game to opposing running backs. He should be fired up as a high-upside RB2 on Monday night.

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Las Vegas Raiders running back Raheem Mostert struggled to make an impact in his change-of-pace role during Week 5, totaling just 22 yards on a season-high seven touches. While the 33-year-old veteran still flashes big-play ability--highlighted by a 37-yard run against the Bears earlier this year--his current workload leaves him well outside fantasy relevance. Mostert should be viewed strictly as a handcuff to rookie standout Ashton Jeanty, who has firmly established himself as the lead back. Still, with Dylan Laube and Zamir White buried on the depth chart, Mostert remains the clear next man up if Jeanty were to miss time. For now, he's best left on the waiver wire outside of deeper leagues or as insurance for Jeanty managers looking to protect one of fantasy's rising assets.

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Tampa Bay Buccaneers quarterback Baker Mayfield (knee, arm) was removed from the injury report ahead of the Week 6 matchup against the San Francisco 49ers. Mayfield has been nursing some minor injuries, but will be fine for this weekend. Last week, Mayfield threw for a season-high 379 yards with two touchdowns and zero interceptions in the win over the Seattle Seahawks. The Bucs are banged up on offense with Bucky Irving (foot), Mike Evans (hamstring), and Chris Godwin (leg) likely all out this weekend. Despite that, Mayfield will find a way to succeed and remain an elite QB1 play.

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The Athletic's Daniel Popper speculates that if the Los Angeles Chargers explore the trade market at running back with Najee Harris (Achilles) done for the year and rookie first-rounder Omarion Hampton (ankle) on Injured Reserve, two potential options could be New York Jets RB Breece Hall and the Cleveland Browns' Jerome Ford. Both Hall and Ford are on expiring deals and could bring the Bolts a compensatory draft pick if they make it to free agency in 2026. Even when Hampton returns from IR, L.A. is going to need a second back to pair with him as a team with a run-first identity under offensive coordinator Greg Roman. At least for Week 6 against the Miami Dolphins, Hassan Haskins and Kimani Vidal are expected to share the backfield equally, giving them both flex appeal in deeper fantasy leagues. How aggressive the Chargers are on bringing in an outside RB will depend on how Haskins and Vidal fare in the coming weeks.

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Buffalo Bills tight end Dalton Kincaid (oblique) is dealing with an oblique injury and was limited in practice for the second straight day this week on Friday. Kincaid was seen wearing a no-contact jersey in practice on Thursday and again had his reps limited in practice on Friday, putting his status up in the air for Monday night's game against the Atlanta Falcons. If the 25-year-old doesn't go full in practice on Saturday, he could draw a questionable tag going into Monday's contest. Kincaid has already scored a career-high three times in his first five games in 2025 and is coming off his first 100-yard game in the Week 5 loss to the New England Patriots. As long as he's active, Kincaid should be considered a top-10 fantasy tight end, but a questionable tag this week could make for a difficult decision for fantasy managers in Week 6. Dawson Knox would be in play as a TE2 streamer if Kincaid is unable to play this week.

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Las Vegas Raiders rookie running back Ashton Jeanty continues to earn a larger role in the offense, showing off his versatility once again in Week 5 against the Colts. Jeanty drew seven targets, catching five passes and racking up 109 total yards from scrimmage despite not finding the end zone. His growing involvement as both a runner and receiver provides a strong floor for fantasy managers, especially with the Raiders offense increasingly leaning on him amid Geno Smith's turnover issues and Brock Bowers' absence. Heading into Week 6, Jeanty gets a dream matchup against a Tennessee Titans defense that ranks 29th against the run. With consistent usage and an expanding role in the passing game, Jeanty should be viewed as a strong RB2 with RB1 upside in PPR formats and a must-start in all standard leagues.

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Green Bay Packers kicker Brandon McManus (quadriceps) is listed as questionable to play in Week 6 on Sunday against the visiting Cincinnati Bengals at Lambeau Field, according to Wes Hodkiewicz of Packers.com. However, despite his questionable status after injuring his quad in practice on Wednesday, McManus told reporters on Thursday that, "I plan on playing." The veteran field-goal kicker felt a "tug" in his quad while warming up for field goals on Wednesday. The 12th-year kicker was limited in all three practices this week. McManus appears to be on the right side of questionable, but fantasy managers will still want to check Sunday's lineup to see if he's active. The 34-year-old will be a little riskier in fantasy lineups because of his injury, but if active, he deserves to be started against a soft Bengals defense. McManus has gone 7-for-9 on field goals and 11-for-12 on extra points in his first four games of 2025.

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Las Vegas Raiders quarterback Geno Smith continues to struggle, watching his fantasy stock take another major hit after tossing multiple interceptions against the Colts. Smith now leads the league with nine picks, a troubling trend that has tanked his reliability in all fantasy formats. With tight end Brock Bowers sidelined and the offense shifting focus toward rookie running back Ashton Jeanty, Smith has fallen to QB24 in overall rankings, rendering him unstartable in standard leagues. While a Week 6 matchup against Tennessee's 21st-ranked pass defense might appear favorable, the Titans' opportunistic secondary--boasting a 10.9% turnover rate--poses a real threat to Smith's chances of rebounding. Fantasy managers should look elsewhere until Smith proves capable of protecting the football and reigniting an offense that has lost its rhythm.

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Chicago Bears tight end Colston Loveland (hip) was a limited participant during Friday's practice session. This is now back-to-back limited practice sessions for Loveland after he missed Week 4 due to a hip issue. The rookie tight end had all last week to rest because of the bye, but is still battling a lingering hip problem. He'll get another chance to practice on Saturday ahead of the Monday night matchup against the Washington Commanders. When healthy, Loveland hasn't done much on the field this season. He has three receptions for 43 yards heading into this Week 6 matchup. Loveland isn't someone that needs to be started in fantasy leagues at the moment.

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Washington Commanders quarterback Jayden Daniels returned to action in Week 5 against the Chargers after missing two games with a knee injury. Daniels didn't miss a beat in Washington's road win in Los Angeles, completing 15 of 26 passes for 231 yards and a touchdown while adding 39 yards on the ground on eight rushes. The second-year quarterback was a bit rusty on his first couple of drives, but quickly settled in and looked like the same dynamic player that took the league by storm last year with one of the best rookie quarterback seasons of all time. Daniels and Washington will face the Bears off a bye in Week 6 in a rematch of their memorable game last season, which dramatically ended on a Hail Mary. It's an exploitable matchup versus a Chicago defense that is allowing nearly 30 points per game and a league-worst 6.7 yards per play. Daniels will rank as the top quarterback in fantasy in what could be a shootout on Monday night.

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Washington Commanders running back Chris Rodriguez Jr. (calf) was unable to practice on Friday. This marks back-to-back days that Rodriguez has been sidelined due to a lingering calf injury. He'll get one more chance to practice on Saturday ahead of the Monday night matchup against the Chicago Bears. If he sits, Jacory Croskey-Merritt should see his role increase in the backfield. The rookie back rushed for 111 yards with two touchdowns on 14 attempts in Week 5. He could see more carries if Rodriguez is unable to play.

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Washington Commanders wide receiver Deebo Samuel Sr. (heel) was a limited participant during Friday's practice session. After sitting out on Thursday, Samuel was back on the field on Friday. Fantasy managers shouldn't be too concerned as the Commanders were just resting Samuel on Thursday. He's dealing with a minor heel issue, but that shouldn't impact his status for the Monday night matchup against the Chicago Bears. Fellow wideout Terry McLaurin (quad) is still banged up, so Samuel should be a fine WR2 for Week 6.

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Detroit Lions tight end Brock Wright has just five catches for 37 yards on six targets so far this season, but two of his catches have resulted in touchdowns. The 27-year-old plays a consistent role in the Lions' offense, as he's played at least 40% of the team's offensive snaps in four out of five games this season. However, Wright's primary usage will likely be as a blocker as long as top Lions tight end Sam LaPorta remains healthy. In 63 career games played for Detroit, Wright has recorded 61 catches for 561 yards and 11 touchdowns. Wright and the Lions have a difficult matchup in Week 6 against the Kansas City Chiefs, who have allowed the ninth-fewest passing yards (999) and the fourth-fewest number of passing touchdowns (five) in the NFL so far this season. Wright should remain off the radar of fantasy managers in Week 6.

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